Unraveling patient-specific neuronal responses to hypoxia and neuroprotective treatments
Patients with cerebral ischemia, including cardiac arrest survivors, have variable outcomes. This patient variation cannot be fully explained by variation in reperfusion. Inter-individual differences in neuronal responses to ischemia and recovery may play a role.
Aim of the MINDSET study is to unravel (variation in) patient-specific neuronal responses to hypoxia-ischemia and potential neuroprotective treatments. To achieve this, we test responses to hypoxia and potential treatments in patient-specific cultured neuronal networks derived from human-induced pluripotent stem cells (‘brain-on-a-chip’). Outcome measures include electrophysiological recordings from multi-electrode arrays (MEAs) and microscopy. The study protocol can be found here.
Team:
- Principal investigator: Dr. ir. M. Frega (University of Twente)
- Study coordinator & PhD candidate: drs. E.J.H.F. Voogd (University of Twente)
Participating centers:
- University of Twente (M. Frega, E.J.H.F. Voogd, J. Hofmeijer)
- Rijnstate Hospital (J. Hofmeijer)
Brain outcome after cardiac arrest 